Table 3.

Antiviral activity of microbicides against mock-exposed and SEVI-exposed HIV-1 in TZM-bl cells or CEMx-M7 cells.

Compound	Class	Inhibitory Concentration 50% (IC50)			Fold increase in IC50 of SEVI-exposed relative to non- exposed HIV
		0.5 ng HIV	0.05 ng HIV	0.05 ng HIV + SEVI	0.5 ng HIV	0.05 ng HIV
SPL7013	Polyanion	1.1±0.1 μg/ml	0.9±0.1 μg/ml	20.1±1.5 μg/ml	19	22
PSA	Polyanion	1.1±0.2 μg/ml	1.2±0.1 μg/ml	21.4±2.5 μg/ml	20	19
2F5	Neutralizing antibody	3.4±0.2 μg/ml	3.5±0.4 μg/ml	23.1±1.0 μg/ml	7	7
TDF	NtRTI	1.7±0.1 nM	2.0±0.3 nM	16.1±1.4 nM	10	8
EVG	Integrase inhibitor	0.63±0.08 nM	0.66±0.11 nM	4.3±0.6 nM	7	6
IDV (CEMx-M7 cells)	Protease inhibitor	2.0±0.3 nM	3.1±1.7 nM	28.4±3.1 nM	14	17
MVC	CCR5 antagonist	3.1±0.4 nM	3.4±0.5 nM	4.4±0.5 nM	1.4	1.3