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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: Neuropharmacology. 2014 Mar 16;82:41–48. doi: 10.1016/j.neuropharm.2014.03.004

Fig. 2.

Fig. 2

Effect of repeated pressure ejections of nicotine on the amplitudes and decay rates of glutamatergic transients (Experiment 1). a The first administration of nicotine (4 nmol) into mPFC evoked glutamatergic transients with a peak amplitude of 10.92 ± 2.90 μM. Except for the amplitudes evoked by the 5th and last pressure ejection of nicotine, at t = 270 min, amplitudes remained stable over time (see Results for ANOVA). b The average decay rate (t50) of nicotine-evoked glutamate signals at T0 was 4.0 ± 0.63 s and there were no effects of repeated pressure ejections of nicotine on this measure. The amplitudes and decay rates of glutamatergic transients evoked by nicotine at t = 0 did not differ between Experiments 1–4 (see Results; post hoc comparisons indicated in figures: *,**,***: p < 0.05, 0.01, 0.001).