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. 2015 Mar 24;10(3):e0119387. doi: 10.1371/journal.pone.0119387

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© 2015 Siddappa et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — Treatment of immature mice with single dose of 25μg/g of PD0325901 inhibited the expression of hCG-induced genes involved in follicular rupture like Ptgs2, Pgr, Adamts1; genes involved in cumulus expansion like Has2, Ptx3, Tnfaip6; gene involved in oocyte meiotic maturation like Areg and luteinization like Cebpb (n = 3mice/group/time point). Mapk3/1 regulated LH induced genes like Ptgs2, Ptx3 and Tnfaip6 were not regulated by Cebpb.