Table 2. Biological genes in the CRC risk loci with a score≥2.

SNP	gene	Nearest gene from risk SNP	missense variant	cis-eQTL	pubmed text-mining	PPI	cancer somatic mutation genes	knockout mouse phenotype	function	score
rs3217810	CCND2	1	-	1	1	-	1	1	1	5
rs10774214	CCND2	1	-	-	1	-	1	1	1	4
rs1321311	CDKN1A	1	-	1	1	-	-	1	1	4
rs4444235	BMP4	1	-	1	1	-	-	1	1	4
rs9929218	CDH1	1	-	-	1	-	1	1	1	4
rs10114408	BARX1	1	-	-	1	-	-	1	1	3
rs10411210	RHPN2	1	-	-	1	-	-	1	1	3
rs10911251	LAMC1	1	-	-	1	-	-	1	1	3
rs10911251	LAMC2	-	-	-	1	-	-	1	1	3
rs13130787	ATOH1	1	-	-	1	-	-	1	1	3
rs39453	CYCS	1	-	1	-	-	-	1	1	3
rs4813802	BMP2	1	-	-	1	-	-	1	1	3
rs4925386	LAMA5	1	-	1	1	-	-	-	1	3
rs4939827	SMAD7	1	-	-	1	-	-	1	1	3
rs59336	TBX3	1	-	-	1	-	-	1	1	3
rs647161	PITX1	-	-	-	1	-	-	1	1	3
rs7315438	TBX3	1	-	-	1	-	-	1	1	3
rs11169552	ATF1	-	-	-	-	-	1	1	-	2
rs11632715	GREM1	-	-	-	1	-	-	-	1	2
rs12548021	DUSP4	1	-	-	-	-	-	1	1	2
rs16969681	GREM1	-	-	-	1	-	-	-	1	2
rs17094983	DACT1	1	-	-	1	-	-	1	-	2
rs1912453	RGS4	-	-	-	-	-	-	1	1	2
rs1957636	CDKN3	1	-	-	1	-	-	-	1	2
rs2057314	ROS1	-	-	-	-	-	1	1	-	2
rs2057314	GOPC	1	-	-	-	-	1	-	1	2
rs367615	MAN2A1	1	-	-	-	-	-	1	1	2
rs3802842	C11orf53	-	-	-	1	1	-	-	-	2
rs4779584	GREM1	-	-	-	1	-	-	-	1	2
rs7758229	SLC22A3	1	-	-	-	-	-	1	1	2
rs8180040	PTPN23	-	1	-	-	-	-	-	1	2
rs8180040	PTH1R	-	-	-	-	-	-	1	1	2
rs8180040	SETD2	-	-	-	-	-	1	1	-	2
rs9365723	SYNJ2	1	-	1	-	-	-	-	1	2
rs9929218	CDH3	-	-	-	1	-	-	1	-	2