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. 2015 Mar 24;10(3):e0122661. doi: 10.1371/journal.pone.0122661

Fig 7. Effects of a combination of Rhizoma Coptidis alkaloids, Radix et Rhizoma Rhei polysaccharides, and Radix Scutellaria flavones (APF) on cell proliferation and fibrosis in mesangial cells incubated at high glucose.

Fig 7

NG: normal glucose; HG: high glucose; APF 4, 8, and 16 μg /mL represent mesangial cells incubated in high glucose concentration treated with 4, 8, and 16 μg /mL APF, respectively. (a-d) Western blot analysis of α-SMA, CollagenⅠ, TGF-β1 and NF-κB protein levels; (e) Cell proliferation. Data are expressed as mean ±S.D., n = 5 for cell proliferation, and n = 3 for Western blot, *p<0.05, **p<0.01, compared to control cells incubated at high glucose concentration with no APF.