Skip to main content
. 2015 Mar 24;10(3):e0121570. doi: 10.1371/journal.pone.0121570

Fig 3. Memory alterations in low and higher expresser mutant 3R Tau tg mice.

Fig 3

Mice were evaluated for context-dependent learning in an open field area at 8–10 months using a Kinder SmartFrame Cage Rack Station activity monitor system. A. Non-tg controls and 3R Tau tg Line 2 (lower-expresser) mice had reduced levels of activity over time as they became more familiar with the environment in the cage. B and C. Water maze testing presented as distance traveled and time to find the platform, respectively. During the cued portion of the test both the non-tg and mutant 3R Tau tg mice performed as expected. However during the hidden portion of the test, the higher expresser (Line 13) 3R Tau tg mice took a longer time and went a farther distance to find the platform compared to the non-tg. The lower expresser 3R Tau Line 2 mice was comparable to non-tg controls for distance but took longer a time to find the platform during the hidden portion of the test. D. At day 8, during the probe portion of the test (with platform removed) both Lines 2 and 13 displayed impairments in memory retention, E. Probe test with the visual platform confirmed that no visual alterations were detected. N = 12 non-tg, N = 12 3R Tau tg Line 2, N = 12 3R Tau tg Line 13. * = P < 0.05 compared with non-tg by one-way ANOVA with Dunnett’s post hoc analysis. # = P < 0.05 when comparing Line 2 and 13 using one way ANOVA with Fisher’s posthoc test.