Skip to main content
. 2015 Mar 24;10(3):e0121570. doi: 10.1371/journal.pone.0121570

Fig 5. Effects of aging on memory and motor activity in higher expresser 3R Tau tg mice.

Fig 5

A. Context-dependent open field showed no alterations in 3–4 m old 3RTau tg mice, while mice at 6–8 and 12–14 months of age displayed similar level of alteration. B. Motor testing in the round beam showed that at 3–4 months of age the higher expresser 3R Tau Line 13 mice performed at a similar level to non-tg when crossing the beam, while at 6–8 and 12–14 months of age the 3R Tau Line 13 mice showed impairments with a higher rate of errors. C. Testing for spontaneous locomotor activity showed increased total activity in Line 13 mice beginning at 3–4 m of age with a time dependent increase 6–8 and 12–14 m of age. 3–4 (N = 10), 6–8 (N = 8) and 12–14 (N = 8) months of age. * = P < 0.05 when compared to non-tg control using one way ANOVA with Dunnett’s post hoc test.