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. 2015 Mar 24;10(3):e0121570. doi: 10.1371/journal.pone.0121570

Fig 7. Effects of aging on 3R Tau accumulation and dendritic loss in the mutant 3R Tau tg mice.

Fig 7

A. Age-dependent increase in the immunoreactivity for 3R Tau in layers II-III and V pyramidal neurons in the neocortex and quantification in the B neocortex and C hippocampus at ages 3–4, 6–8, and 12–14 months of age in Line 13 and non-tg. D. Visualization of MAP2 immunoreactive dendritic densities in the neocortex at ages 3–4, 6–8, and 12–14 months of age in Line 13 and non-tg. Quantification of MAP2 immunoreactivity in the E neocortex and F hippocampus showed that the dendritic densities were preserved in 3R Tau tg mice (Line 13) 3–4 months of age, but were diminished in the older groups. 3–4 (N = 10), 6–8 (N = 8) and 12–14 (N = 8) months of age. * = P < 0.05 when compared to non-tg control using one way ANOVA with Dunnett’s post hoc test.