Fig 4. Regional cerebral glucose metabolism after N-acetyl-L-leucine as compared to sham treatment following unilateral labyrinthectomy.

The images depict group-wise comparisons of the regional cerebral glucose metabolism (rCGM) on days 1, 3, 7 and 15 after unilateral labyrinthectomy (UL). A) Compared to the sham treatment group, the N-acetyl-L-leucine group (24 mg i.v. per rat) showed on day 3 a significant decrease of rCGM in the ipsilesional, on day 7 in the ipsilesional>contralesional posterolateral thalamus and subthalamic region. On day 15 an increase of rCGM was found in the centromedian thalamus and subthalamic region. B) On day 3 rCGM was significantly increased in the ipsilesional, on day 7 in the bilateral paraflocculus/flocculus (vestibulocerebellum) in the N-acetyl-L-leucine group. C) There was no decrease of rCGM in the vestibular nuclei. R right, L left, C caudal, Ro rostral, Ce cerebellum, St subthalamic region, Th thalamus; p-value < 0.001