Fig 6. Regional cerebral glucose metabolism after N-acetyl-L-leucine as compared to N-acetyl-D-leucine treatment following unilateral labyrinthectomy.

The images depict group-wise comparisons of the regional cerebral glucose metabolism (rCGM) on days 1, 3, 7 and 15 after unilateral labyrinthectomy (UL). A) Comparison of the N-acetyl-L-leucine group and the N-acetyl-D-leucine group (24 mg i.v. per rat each) revealed a significant decrease of rCGM in the contralesional>ipsilesional posterolateral thalamus on day 3 and 7. B) On day 3 rCGM was significantly increased in the ipsilesional, on day 7 in the ipsilesional>contralesional paraflocculus/flocculus (vestibulocerebellum) in the N-acetyl-L-leucine group. R right, L left, C caudal, Ro rostral, Ce cerebellum, St subthalamic region, Th thalamus; p-value < 0.001