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. 2015 Mar 24;11(3):e1005063. doi: 10.1371/journal.pgen.1005063

Fig 9. Accumulation of GlcCer alters lipid packaging of the plasma membrane.

Fig 9

Analysis of lipid packaging in GPMVs isolated from wild-type (+/+, black line), GBA2 knockout-fibroblasts (-/-, red line), and wild-type fibroblasts treated for 48 h with 2 μM NB-DNJ (blue line). GPMVs were labeled with 5 μM laurdan and analyzed by fluorescence spectroscopy. Representative emission spectra normalized to the maximum are shown. GP index has been calculated and presented as mean ± S.D. (p = 0.001); n numbers are indicated in brackets.