Table 3. Physical-chemical properties of prevalent amine-containing drugs state at the intercalation pH.
| Drug | Non-ionized/ionized | |||||
|---|---|---|---|---|---|---|
| Dipole a | LogP | LogD | HBD | HBA | Volume (Å3) | |
| RVT c | 9.49 | −1.09 | −0.94 | 1 | 4 | 257.48 |
| DXZ c | 13.88 | 0.31 | 0.43 | 2 | 10 | 394.36 |
| 5FU b | 3.84 | −0.66 | −0.66 | 2 | 4 | 93.61 |
| CLX c | 18.53 | −8.48 | −4.92 | 10 | 10 | 446.41 |
| ODP c | 20.72 | 2.04 | 3.20 | 1 | 3 | 296.10 |
| ACV c | 9.05 | −2.03 | −1.61 | 4 | 8 | 186.15 |
| DPS c | 18.63 | −0.97 | 0.63 | 2 | 5 | 213.85 |
| NTT c | 15.35 | −3.44 | −3.00 | 12 | 18 | 886.80 |
| PSA d | 14.29 | −0.82 | −0.11 | 1 | 6 | 214.93 |
aDipole moment in debye (D)
bnon-ionized drug
cprotonated drug
ddeprotonated drug.