Table 1. Univariate analysis of characteristics associated with hospital mortality of cancer patients admitted with pneumonia acquired out of hospital setting.
| All Patients n = 325 (100%) | Survivors n = 114 (35%) | Nonsurvivors n = 211 (65%) | P-value | |
|---|---|---|---|---|
| Age (years) | 66 (55.5–73) | 64 (52.75–72) | 67 (57–75) | 0.307 |
| Male gender | 203 (63%) | 70 (61%) | 133 (63%) | 0.811 |
| Performance status | ||||
| 0–1 | 174 (54%) | 68 (60%) | 106 (50%) | 0.130 |
| 2–4 | 148 (46%) | 45 (40%) | 103 (49%) | |
| Previous hospitalization 1 | 106 (33%) | 39 (34%) | 67 (32%) | 0.710 |
| Previous chemotherapy 2 | 109 (34%) | 35 (31%) | 74 (35%) | 0.462 |
| Previous radiation therapy 3 | 35 (11%) | 12 (11%) | 23 (11%) | 0.999 |
| Attended a hospital, nursing home or hemodialysis clinic | 49 (15%) | 26 (23%) | 23 (11%) | 0.006 |
| Solid tumors | 229 (71%) | 77 (68%) | 152 (72%) | 0.445 |
| Hematologic malignancy | 96 (30%) | 37 (33%) | 59 (28%) | |
| Hospital LOS prior to ICU admission | 1 (0–2) | 1 (0–2) | 1 (0–2) | 0.101 |
| Charlson comorbidity index (points) | 3 (2–6) | 3 (2–5) | 3 (2–6) | 0.702 |
| Neutropenia | 35 (11%) | 11 (10%) | 24 (11%) | 0.710 |
| Septic shock at ICU admission | 244 (75%) | 63 (55%) | 181 (86%) | <0.001 |
| SOFA on Day 1 (points) | 7 (5–10) | 6 (3.75–8.25) | 8 (6–11) | <0.001 |
| SAPS II (points) | 50 (38–61) | 45 (34–54) | 52 (43–65.5) | <0.001 |
| Ventilatory support category | ||||
| None | 28 (9%) | 22 (19%) | 6 (3%) | <0.001 |
| Noninvasive mechanical ventilation (NIV) only | 35 (11%) | 24 (21%) | 11 (5%) | <0.001 |
| NIV followed by MV | 50 (15%) | 15 (13.2%) | 35 (17%) | 0.520 |
| Invasive MV only | 262 (81%) | 68 (60%) | 194 (92%) | <0.001 |
| RRT | 88 (27%) | 11 (10%) | 77 (37%) | <0.001 |
| Corticosteroids use 30 days before | 97 (30%) | 34 (30%) | 63 (30%) | 0.999 |
1- Previous hospitalization is defined when a patient was hospitalized in an acute care hospital for two or more days within 90 days of the infection.
2- Previous chemotherapy is defined as chemotherapy within the past 30 days of the current infection.
3- Previous radiation therapy is defined as radiation therapy within the past 30 days of the current infection.
Definition of abbreviations: LOS = length of stay; ICU = intensive care unit; NIV = noninvasive ventilation; SOFA score = sequential organ failure assessment score; SAPS score = simplified acute physiology score; RRT = renal replacement therapy