Table 4.
Magnitude of association between type of intra-amniotic inflammation and risk of spontaneous preterm delivery at <34 weeks of gestation both unrestricted and restricted to patients whose diagnosis of a sonographic short cervix was performed <24 weeks of gestation.
| Study Group | n | % | Unadjusted | Adjusted* | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| HR | 95%CI | HR | 95%CI | |||||
|
All the study population
| ||||||||
| No MIAC or intra-amniotic inflammation | 174 | 75 | 1 | reference | 1 | reference | ||
| MIAC | 24 | 11 | 1.0 | 0.3 | 3.5 | 1.0 | 0.3 | 3.1 |
| Microbial-associated intra-amniotic inflammation^ | 5 | 2 | 4.8 | 0.7 | 31.2 | 3.9 | 0.6 | 26.0 |
| Sterile intra-amniotic inflammation | 28 | 12 | 3.9 | 1.9 | 7.8 | 3.6 | 1.6 | 8.0 |
|
| ||||||||
|
Sonographic short cervix <24 weeks
| ||||||||
| No MIAC or intra-amniotic inflammation | 77 | 71 | 1 | reference | 1 | reference | ||
| MIAC | 15 | 14 | 1.6 | 0.4 | 5.9 | 1.6 | 0.5 | 5.0 |
| Microbial-associated intra-amniotic inflammation^ | 3 | 3 | 13.6 | 4.7 | 39.3 | 14.7 | 2.8 | 75.8 |
| Sterile intra-amniotic inflammation | 13 | 12 | 4.3 | 1.8 | 10.5 | 5.4 | 1.5 | 19.0 |
Note: multivariable adjustments were made for maternal age, nulliparity, race, 17 OHPC treatment, smoking status and pre-pregnancy body mass index.
Interpretation of these hazard ratios should take into account the small number of subjects.
HR, hazard ratio,