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. Author manuscript; available in PMC: 2016 Mar 24.
Published in final edited form as: J Matern Fetal Neonatal Med. 2014 Sep 24;28(11):1343–1359. doi: 10.3109/14767058.2014.954243

Table 4.

Magnitude of association between type of intra-amniotic inflammation and risk of spontaneous preterm delivery at <34 weeks of gestation both unrestricted and restricted to patients whose diagnosis of a sonographic short cervix was performed <24 weeks of gestation.

Study Group n % Unadjusted Adjusted*

HR 95%CI HR 95%CI
All the study population
No MIAC or intra-amniotic inflammation 174 75 1 reference 1 reference
MIAC 24 11 1.0 0.3 3.5 1.0 0.3 3.1
Microbial-associated intra-amniotic inflammation^ 5 2 4.8 0.7 31.2 3.9 0.6 26.0
Sterile intra-amniotic inflammation 28 12 3.9 1.9 7.8 3.6 1.6 8.0

Sonographic short cervix <24 weeks
No MIAC or intra-amniotic inflammation 77 71 1 reference 1 reference
MIAC 15 14 1.6 0.4 5.9 1.6 0.5 5.0
Microbial-associated intra-amniotic inflammation^ 3 3 13.6 4.7 39.3 14.7 2.8 75.8
Sterile intra-amniotic inflammation 13 12 4.3 1.8 10.5 5.4 1.5 19.0

Note: multivariable adjustments were made for maternal age, nulliparity, race, 17 OHPC treatment, smoking status and pre-pregnancy body mass index.

^

Interpretation of these hazard ratios should take into account the small number of subjects.

HR, hazard ratio,