. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: J Antibiot (Tokyo). 2014 Sep 24;68(3):191–196. doi: 10.1038/ja.2014.125

Table 3.

Activity of compounds 1–11 against two human tumor cell lines

	IC₅₀ values in μM^b
Compound^a	MDA-MB-435^c	SW-620^c
1	1.5	0.5
3	67.9	16.0
4	65.2	15.1
5	2.3	2.5

Compounds 2 and 6–11 were inactive.

IC₅₀ values were determined as the concentration required to inhibit growth to 50% of control with a 72 h incubation.

Positive control was vinblastine tested at concentration of 1 nM in MDA-MB-435 cells and 10 nM in SW620 cells, which had 48% and 30% viable cells, respectively.