Table 4.
Antifungal and hemolytic activity of compounds 1, 3, and 5
| Minimal inhibitory concentration (μg/ml) |
10% Hemolysis (μg/ml)a | Safety factorb | |||
|---|---|---|---|---|---|
| Compound | C. albicans | C. neoformans | A. niger | ||
| 1 | >53 | >53 | 0.05 | 52.5 | 1050 |
| 3 | >38 | >38 | 0.60 | 37.5 | 62.5 |
| 5 | >45 | >45 | 0.04 | 45.0 | 1125 |
| Amphotericin Bc | 16 | 8 | 31 | 62.5 | 2.0 |
| Triton X-100c | NT | NT | NT | 0.40 | NA |
a
Hemolytic activity is the concentration required to provoke 10% hemolysis
b
Safety factor was calculated as the concentration inducing 10% hemolysis over MIC against A niger.
c
Positive controls.
Abbreviations: NT. not tested. NA. not available.