Fig 1. Simplified pedigrees for the 7 whole exome sequencing families.

Only sequenced individuals and those needed to preserve generational structure are shown to protect the anonymity of the pedigree. IA = intracranial aneurysm. All affected individuals are definite IA unless noted as a probable IA, possible IA, or aortic abdominal aneurysm (AAA). Criteria for defining definite, probable, and possible IA statuses are outlined in Table 1. All unaffected individuals, with the exception of individual E-9, had an MRA performed that did not show evidence of an IA. Grey indicates an unknown phenotype. An ‘S’ above an individual denotes that the individual was selected for sequencing.