Table 3. Insertion deletion filtering pipeline.

Family	A	B	C	D	E	F	G	All
All variants found in at least one definite IA	3316	2736	3226	3166	3396	2987	2966	5851
(1) Autosomal variants	3264	2705	3178	3102	3345	2940	2921	5737
(2) Variants predicted to be functional	538	457	560	541	581	511	465	1126
(3) Rare variants	284	221	299	277	299	266	260	589
(4) Variants not found or of low frequency in the internal allele frequency database	178	159	188	171	192	165	157	453
(5) Variants predicted damaging	60	59	65	50	59	55	42	194
(6) Variants segregating with all definite IA in at least one family	24	22	23	19	23	24	19	26
Variants passing visual inspection and manual review with internal database calls	0	0	0	0	0	0	1	1
A. Variants segregating with all IA (definite, probable, possible) or AAA in at least one family	0	0	0	0	0	0	0	0
B. Variants not found in unaffected individuals	0	0	0	0	0	0	0	0

Numbers in parentheses refer to filtering steps described in the Methods. IA = intracranial aneurysm