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A) and B). Immunoblotting of p-Smad and Smad levels in kidney cortex homogenates from four groups of mice. C) kidney collagen IV levels were detected using immunohistochemical staining, followed by semiquantitative analysis (D). Data are represented as mean ± SE (n = 6–10 mice/group). ** P<0.01 vs. LF ApoE-/-. # P<0.05, ### P<0.001vs. HF ApoE-/-.
