Table 2. Comparison of CD4+ T cell subset percentages in adults and children in control and CF groups.
| Adults | Children and adolescents | |||||
|---|---|---|---|---|---|---|
| Control | CF | P value* | Control | CF | P value* | |
| N | 51 | 20 | 17 | 22 | ||
| Age median (range) | 22 (18–61) | 24 (18–53) | 0.13 | 8 (2–17) | 11 (0.5–17) | 0.22 |
| Sex male (%) | 24 (47%) | 12 (60%) | 9 (51%) | 8 (36%) | ||
| CD4+% median (range) | 50.4 (29.7–66.0) | 47.4 (28.3–66.1) | 0.18 | 42.1 (32.7–52.6) | 46.8 (33.2–61) | 0.15 |
| Th1% median (range) | 9.6 (3.0–22.4) | 8.5 (3.5–24.6) | 0.82 | 4.6 (3.0–9.6) | 5.4 (1.2–10.7) | 0.98 |
| Th2% median (range) | 2.5 (0.7–9.8) | 2.3 (0.4–8.5) | 0.74 | 1.4 (0.4–5.0) | 1.2 (0.4–8.4) | > 0.99 |
| Th1/Th2 median (range) | 4.6 (1.3–11.3) | 5.1 (1.0–10.4) | 0.67 | 3.8 (1.3–8.5) | 3.9 (0.7–8.8) | 0.91 |
| Th17% median (range) | 0.49 (0.15–2.26) | 0.52 (0.04–1.98) | 0.77 | 0.37 (0.08–1.08) | 0.36 (0.03–1.02) | 0.79 |
| Treg% median (range) | 5.5 (1.8–10.5) | 6.8 (4.2–11.4) | 0.008 | 7.6 (3.5–11.2) | 7.2 (2.5–12.8) | 0.77 |
| Treg/Th17 | 10.6 (2–37) | 14.8 (4–441) | 0.32 | 18.6 (6.9–57) | 18.6 (3.2–305) | 0.93 |
| IL-10+% median (range) | 1.15 (0.35–2.63) | 1.77 (0.41–4.16) | 0.0004 | 1.27 (0.70–3.32) | 1.5 (0.66–2.85) | 0.29 |
| TGFβ+% median (range) | 0.022 (0.008–0.19) | 0.093 (0.018–0.417) | < 0.0001 | 0.044 (0.020–0.143) | 0.043 (0.017–0.301) | 0.86 |
*P-values (Mann—Whitney) of significant differences are shown bold