Table 3. Associations of CD4+ subset percentages with demographic and clinical variables in the CF group.
| Parameter [no. of patients] | CD4% | Th1% | Th2% | Th17% | Treg% | IL-10+% | TGFβ+ | Th1/Th2 | Treg/Th17 |
|---|---|---|---|---|---|---|---|---|---|
| Age [42] (Spearman r) | –0.032 | 0.56 | 0.44 | 0.23 | 0.06 | 0.12 | 0.29 | 0.16 | –0.11 |
| P-value* | [0.84] | [0.002] | [0.018] | [0.16] | [0.73] | [0.46] | [0.07] | [0.43] | [0.51] |
| FEV1% pred. [32] (Spearman r) | –0.01 | –0.45 | –0.31 | –0.56 | –0.42 | 0.003 | 0.04 | –0.25 | –0.12 |
| P-value | [0.95] | [0.06] | [0.19] | [0.0008] | [0.016] | [0.99] | [0.82] | [0.28] | [0.57] |
| FEV1% pred. stable patients only [25] (Spearman r) | –0.13 | –0.45 | –0.31 | –0.58 | –0.31 | 0.16 | 0.16 | –0.10 | –0.14 |
| P-value | [0.52] | [0.06] | [0.19] | [0.0017] | [0.12] | [0.44] | [0.44] | [0.68] | [0.52] |
| Median percent for each subset | |||||||||
| Sex | |||||||||
| Male | 46.3 | 7.8 | 1.80 | 0.43 | 7.1 | 1.60 | 0.090 | 4.8 | 14.4 |
| Female | 48.2 | 5.7 | 1.42 | 0.40 | 6.9 | 1.67 | 0.055 | 4.7 | 17.0 |
| P-value | [0.25] | [0.38] | [0.32] | [0.49] | [0.96] | [0.69] | [0.13] | [0.84 | [0.30] |
| Genotype | |||||||||
| DF508 homozygous [18] | 47.8 | 5.7 | 1.55 | 0.41 | 6.7 | 1.76 | 0.053 | 4.9 | 13.3 |
| DF508 heterozygous/other [24] | 46.8 | 6.2 | 1.42 | 0.43 | 7.6 | 1.47 | 0.069 | 4.8 | 19.5 |
| P-value | [0.74] | [0.85] | [0.99] | [0.69] | [0.12] | [0.48] | [0.66] | [1.0] | [0.28] |
| Stable [35] | 47.0 | 6.2 | 1.42 | 0.43 | 7.0 | 1.65 | 0.053 | 4.7 | 17.0 |
| Exacerbating [7] | 48.2 | 13.1 | 2.35 | 0.65 | 7.1 | 1.56 | 0.079 | 5.90 | 9.9 |
| P-value | [0.94] | [0.26] | [0.32] | [0.14] | [0.60] | [0.99] | [0.76] | [0.13] | [0.18] |
| Chronic P. aeruginosa [15] | 46.6 | 9.6 | 2.32 | 0.66 | 6.8 | 1.44 | 0.095 | 5.8 | 11.2 |
| No chronic P. aeruginosa [27] | 47.8 | 5.7 | 1.63 | 0.36 | 7.3 | 1.63 | 0.041 | 3.9 | 18.7 |
| P-value | [0.42] | [0.17] | [0.42] | [0.09] | [1.0] | [0.69] | [0.006] | [0.04] | [0.18] |
| Current S. aureus infection [16] | 48.1 | 5.7 | 2.11 | 0.42 | 6.8 | 1.77 | 0.044 | 4.8 | 16.6 |
| No S. aureus infection [26] | 46.5 | 6.4 | 1.42 | 0.51 | 7.1 | 1.63 | 0.088 | 4.7 | 13.8 |
| P-value | [0.59] | [0.79] | [0.50] | [0.51] | [0.76] | [0.53] | [0.17] | [0.87] | [0.34] |
| Current A. fumigatus infection [7] | 46.3 | 8.9 | 1.80 | 0.43 | 6.3 | 1.54 | 0.091 | 4.9 | 18.8 |
| No A. fumigatus infection [35] | 47.5 | 5.4 | 1.52 | 0.43 | 7.1 | 1.65 | 0.048 | 4.4 | 15.8 |
| P-value | [0.42] | [0.06] | [0.36] | [0.92] | [0.48] | [0.75] | [0.25] | [0.56] | [0.97] |
| Any current antimicrobial [21]) | 47.6 | 8.5 | 2.0 | 0.71 | 6.8 | 1.76 | 0.092 | 5.2 | 9.3 |
| No current antimicrobial (21] | 46.6 | 5.7 | 1.69 | 0.34 | 7.1 | 1.54 | 0.041 | 3.7 | 18.8 |
| P-value | [0.68] | [0.07] | [0.35] | [0.013] | [0.93] | [0.42] | [0.047] | [0.13] | [0.02] |
*P-values indicating significant differences are shown in bold.