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. 2015 Mar 24;10(3):e0120851. doi: 10.1371/journal.pone.0120851

Fig 4. Smad4 deficiency significantly enhanced MT-TGFα-induced epithelial expansion.

Fig 4

Increased number of proliferating ductal cells was observed in the STP mice over the MT-TGFα mice. (A) Ki-67 immunolabeling of pancreata from MT-TGFα (panel i) and STP (panel ii) mice after 8-months of zinc sulfate treatment. Arrows denote proliferating epithelial cells in evolving ADM and PanIN lesions. (B) The graph presents the percentage of Ki-67-positive epithelial cells among the total number of metaplastic cells counted. The table shows the percentage of Ki67-positve cells and in parentheses the total counts of Ki67-positive cells over the total number of metaplastic cells counted from at least three independent mice per genotype and ten 400X fields per mouse are shown. Values are presented as mean ±SE; Magnifications panels i and ii, 400x. (Student’s t-test, * p < 0.05; ** p < 0.01)