Table 1.
Comparison of I-CRC and Sporadic CRC Study Subjects and Tumor Characteristics
| Sporadic CRC (N⁎ = 95) |
I-CRC (N = 46) |
P Value‡ | Combined CIN (N = 116) |
CRC Cohort CIN-Negative (N = 22) |
P Value | |
|---|---|---|---|---|---|---|
| n† (%) | n (%) | n (%) | n (%) | |||
| Subject | ||||||
| Age, mean ± SD (years) | 70.1 ± 8.0 | 70.7 ± 7.9 | .69 | 69.8 ± 8.1 | 72.2 ± 7.1 | .18 |
| Sex | ||||||
| Male | 64 (67.4) | 29 (63.0) | .71 | 74 (81.3) | 17 (18.7) | .33 |
| Female | 31 (32.6) | 17 (37.0) | 42 (89.4) | 5 (10.6) | ||
| Sample | ||||||
| Location | ||||||
| Proximal | 70 (73.7) | 35 (76.1) | .84 | 82 (80.4) | 20 (19.6) | .06 |
| Distal | 25 (26.3) | 11 (23.9) | 34 (94.4) | 2 (5.6) | ||
| TNM stage | ||||||
| 0 | 0 | 1 (2.2) | .78 | 0 | 1 (100.0) | .24 |
| 1 | 11 (11.6) | 6 (13.0) | 17 (100.0) | 0 | ||
| 2 | 35 (36.8) | 15 (32.6) | 35 (72.9) | 13 (27.1) | ||
| 3 | 28 (29.5) | 15 (32.6) | 36 (85.7) | 6 (14.3) | ||
| 4 | 20 (21.1) | 9 (19.6) | 27 (93.1) | 2 (6.9) | ||
| N/D§ | 1 (1.1) | 0 | 1 (100.0) | 0 | ||
| TNM stage (clustered) | ||||||
| 1 and 2 | 46 (48.9) | 21 (46.7) | .86 | 52 (80.0) | 13 (20.0) | .23 |
| 3 and 4 | 48 (51.1) | 24 (53.3) | 63 (88.7) | 8 (11.3) | ||
| Grade | ||||||
| 1 | 8 (8.4) | 3 (6.5) | .72 | 7 (77.8) | 2 (22.2) | .23 |
| 2 | 67 (70.5) | 30 (65.2) | 85 (87.6) | 12 (12.4) | ||
| 3 | 13 (13.7) | 8 (17.4) | 13 (65.0) | 7 (35.0) | ||
| 4 | 1 (1.1) | 0 | 1 (100.0) | 0 | ||
| N/D | 6 (6.3) | 5 (10.9) | 10 (90.9) | 1 (9.1) | ||
| Grade (clustered) | ||||||
| 1 and 2 | 75 (84.3) | 33 (80.5) | .62 | 92 (86.8) | 14 (66.7) | .047 |
| 3 and 4 | 14 (15.7) | 8 (19.5) | 14 (13.2) | 7 (33.3) | ||
| Index colonoscopy¶ | ||||||
| Completed to caecum# | 54 (84) | 33 (79) | .45 | 76 (70.4) | 12 (66.7) | .78 |
| Speciality of physician performing colonoscopy | ||||||
| Gastroenterology | 34 (40) | 9 (21) | .04 | 37 (88.1) | 5 (11.9) | .60 |
| Surgery | 52 (60) | 33 (79) | 69 (83.1) | 14 (16.9) |
⁎
N = total number of samples in the cohort.
†
n = number of samples in sub-category.
‡
P value < .05 is statistically significant.
§
N/D = not determined.
¶
Index colonoscopy = medical records could not be retrieved for all cases. The proportions reported for index colonoscopy are based on the percentage of the reviewed cases. The number of colonoscopies performed by non-gastroenterology, non-surgical specialities was very few and those numbers are not broken down further to protect anonymity of the data.
#
Completed to caecum = excluding colonoscopies with obstructing lesions.