TABLE 1.
Pathway Analysis of Genes in the Liver of Rats Treated with Furan for 90 Days and 360 Days After Furan Treatment
| Category | Pathway | P-Value |
|---|---|---|
| Furan, treatment for 90 daysa | ||
| Immune system | Inflammation | <1.00E + 09 |
| Cell growth and death | Cell cycle and p53 signaling pathway | 9.00E−08 |
| Xenobiotics metabolism and transport | Drug metabolism: cytochrome P450 and ABC transporters | 8.30E−07 |
| Metabolism | Glutathione and amino acid metabolism | 7.33E−06 |
| Fatty acid metabolism and glycolysis | 0.001 | |
| Replication and repair | DNA replication | 0.001 |
| Signal transduction | TGF-beta signaling pathway | 0.05 |
| Furan, 360 after treatmentb | ||
| Metabolism | Amino acid metabolism | 0.006 |
| Cancers | Pathways in cancer | 0.009 |
| Signal transduction | Calcium signaling pathway | 0.012 |
| Digestive system | Carbohydrate digestion and absorption | 0.015 |
a1134 genes, whose expression were significantly different from corn oil-treated controls (fold change >2, P ≤ 0.05; listed in Supplementary Table 3), were analyzed using the KEGG pathway database as described in Materials and Methods.
b88 genes, whose expression were significantly different from corn oil-treated controls (fold change >2, P ≤ 0.05; listed in Supplementary Table 4), were analyzed using the KEGG pathway database as described in Materials and Methods.