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. 2015 Jan 9;144(2):366–381. doi: 10.1093/toxsci/kfv005

FIG. 8.

FIG. 8.

Cytoviva-enhanced dark field images of AgNPs in unstained paraffin embedded lung sections. Cellular AgNPs uptake within the lung was qualitatively evaluated by the assessment of lung sections following exposure to 20 nm AgNP at (A) 1 day, (B) 7 days, and (C) 21 days or 110 nm AgNP at (D) 1 day, (E) 7 days, and (F) 21 days by Cytoviva-enhanced dark field microscopy. (G) AgNPs within lung epithelial cells at 21 days following exposure to 20 nm AgNP. Alterations in mean spectral profiles for (H) 20 nm AgNP and (I) 110 nm AgNP. Mean spectral profiles of AgNPs (black), AgNPs within alveolar macrophages at 24 h (red), and following 24 h incubation with artificial lysosomal fluid (ALF) (blue). Bar = 10 µm.