TABLE 3.
Multi-Path Particle Dosimetry (MPPD) Model Input Parameters and Results
| Input Parameters | 20 nm | 110 nm |
|---|---|---|
| Species | Rat | Rat |
| FRC volume (ml)a | 4.0 | 4.0 |
| Head volume (ml)a | 0.42 | 0.42 |
| Density | 7.24 | 7.24 |
| Diameter (CMD) (nm) | 77b | 110c |
| Geometric SD (σg) | 1.8 | 1.8 |
| Concentration (mg/mb) | 7.2 | 5.3 |
| Breathing frequencya (min−1) | 102 | 102 |
| Tidal volumea (ml) | 2.1 | 2.1 |
| Inspiratory fractiona | 0.5 | 0.5 |
| Pause fractiona | 0 | 0 |
| Breathing scenario | Nasal | Nasal |
| Clearance rated (day−1) | 0.00515 | 0.00515 |
| Output results | ||
| Deposition fraction alveolar region | 0.124 | 0.100 |
| Deposition fraction conducting airways | 0.031 | 0.029 |
| Thoracic deposited fraction | 0.155 | 0.129 |
| Retained alveolar fraction at 56 days | 0.348 | 0.317 |
aDefault value from program (http://www.ara.com/products/mppd.htm).
bSMPS geometric mean diameter.
cSMPS secondary peak diameter.
dJi and Yu (2012) Toxicology Research.