Table 4.
Metabolic characteristics of patients with urolithiasis and hyperuricemia and patients with urolithiasis and normouricemia
| Demographic and metabolic parameters | Urolithiasis group (HU+) (n = 110) | Urolithiasis group (HU−) (n = 368) | p |
|---|---|---|---|
| Age, n (years) | 16.29 (14.93–17.35) | 14.24 (9.95–16.48) | <0.01 |
| Gender, n (female/male) | 34/76 | 239/129 | <0.05a |
| BMI Z-score | 0.37 (−0.33–1.14) | −0.06 (−0.72–0.67) | <0.01 |
| Urine volume (mL/kg/24 h) | 19.38 (11.76–23.81) | 22.04 (15.69–30.00) | <0.01 |
| Creatinine (mg/dL) | 0.78 (0.65–0.85) | 0.56 (0.45–0.67) | <0.01 |
| Cholesterol (mg/dL) | 155 (138–188) | 171 (143–185.5) | NS |
| Glucose (mg/dL) | 90 (83–93) | 88 (84–93) | NS |
| BRI (L−1) | 0.94 (0.08–4.16) | 1.01 (0.16–3.89) | NS |
| Urine pH | 6.28 (5.92–6.50) | 6.34 (6.08–6.61) | NS |
| GFR (mL/min/1.73 m2) | 122.32 (104.83–134.97) | 125.42 (100.95–149.22) | NS |
| Oxalate/cr. (mmol/g cr.) | 0.41 (0.17–0.60) | 0.49 (0.26–0.73) | <0.01 |
| Citrate/cr. (mg/g cr.) | 291.94 (189.80–420.99) | 502.75 (317.30–767.81) | <0.01 |
| Ca/cr. (mmol/g cr.) | 3.24 (1.45–5.38) | 3.66 (2.20–5.92) | <0.05 |
| P/cr. (mmol/g cr.) | 16.51 (13.75–20.47) | 20.77 (16.38–26.82) | <0.01 |
| Mg/cr. (mmol/g cr.) | 2.78 (2.11–3.45) | 3.52 (2.67–4.62) | <0.01 |
| Uric acid/cr. | 0.36 (0.31–0.43) | 0.46 (0.37–0.59) | <0.01 |
| Ca/citrate | 0.41 (0.20–0.78) | 0.30 (0.16–0.56) | <0.05 |
| Fractional excretion of uric acid (%) | 4.02 (3.60–4.94) | 6.08 (5.04–7.60) | <0.01 |
Data are presented as the median with the IQR in parenthesis, unless otherwise indicated
HU+, hyperuricemia; HU−, normouricemia
aThe chi-square statistic was used