TABLE 2.

Calculation of significant differences for Fig. 6B and C

Fig. 6 panel and comparison	Histone PTM	W statistic	P value
Ba
BRD4 vs all genes		2,683,292	<2.2e−16
BRDT vs all genes		1,729,944	<2.2e−16
Cobound vs all genes		378,363	<2.2e−16
Cobound vs BRD4		181,821	2.6e−08
Cobound vs BRDT		127,587	6.8e−11
Cb
BRD4 vs BRDT	H3K9ac	1,403,278	<2.2e−16
BRD4 vs BRDT	H4K5ac	1,484,792	<2.2e−16
BRD4 vs BRDT	H4K8ac	1,466,692	<2.2e−16
BRD4 vs BRDT	H4K12ac	1,468,998	<2.2e−16
BRD4 vs BRDT	H4K16ac	1,444,708	<2.2e−16
BRD4 vs BRDT	H4Kac	1,479,768	<2.2e−16
Cobound vs BRD4	H3K9ac	276,948.5	7.411e−16
Cobound vs BRDT	H3K9ac	158,058	<2.2e−16
Cobound vs BRD4	H4K5ac	273,017.5	2.435e−14
Cobound vs BRDT	H4K5ac	162,835.5	<2.2e−16
Cobound vs BRD4	H4K8ac	277,942.5	2.972e−16
Cobound vs BRDT	H4K8ac	162,476.5	<2.2e−16
Cobound vs BRD4	H4K12ac	272,689	3.232e−14
Cobound vs BRDT	H4K12ac	161,513.5	<2.2e−16
Cobound vs BRD4	H4K16ac	271,330.5	1.027e−13
Cobound vs BRDT	H4K16ac	158,641.5	<2.2e−16
Cobound vs BRD4	H4Kac	277,562	4.223e−16
Cobound vs BRDT	H4Kac	162,543	<2.2e−16

^aComparison of BRD4-bound, BRDT-bound, and cobound gene expression levels.

^bComparison of BRD4-bound, BRDT-bound, and cobound gene promoter acetylation levels.