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. 2015 Mar 24;35(8):1316–1328. doi: 10.1128/MCB.01263-14

FIG 10.

FIG 10

Impaired L-LTP and LTM in LIMK1+/− mice. (A) LTP induced by HFS (four trains of 100 Hz lasting 1 s each delivered at 20-s intertrain intervals) showing that L-LTP was diminished in LIMK1+/− mice and that this impaired L-LTP was rescued by coapplication of 50 μM forskolin during HFS (arrows). (B, C) Learning acquisition graphs of the results of the water maze test showing no differences in either latency (B) or travel distance (C) to locate the hidden platform between LIMK1+/− mice and their WT littermates. (D) Results of a probe test carried out 2 h after the 3rd day of training showing that both LIMK1+/− mice and their WT littermates exhibited a significant bias toward the target zone, suggesting that STM was intact in LIMK1+/− mice. (E) Results of a probe test done at 48 h posttraining showing that LIMK1+/− mice exhibited a significantly reduced bias toward the target zone compared to their WT littermates. Representative traces shown above the graphs were taken at the time points indicated by their respective numbers (1 and 2). Dashed lines indicate 100% and are shown for reference. Error bars represent SEMs. *, P < 0.05; n, number of animals.