FIG 9.

Rescue of LTM of fear in LIMK1^−/− mice by rolipram treatment. (A) During the training phase, both LIMK1^−/− mice and their WT littermates showed similar amounts of freezing before and after the foot shock. After the training, mice were randomly selected for rolipram or DMSO injections, and then STM and LTM were tested at 2 and 48 h posttraining, respectively. (B) All groups performed equally well in the STM test. (C) In the LTM test, LIMK1^−/− mice treated with rolipram performed significantly better than LIMK1^−/− mice treated with DMSO and similarly to their WT littermates. Error bars represent SEMs. *, P < 0.05; n, number of animals.