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Effect of impaired ShcA-mediated signaling in phosphorylation-defective mutant ShcFFF. A schema depicting the role of ShcA downstream of pre-TCR-mediated signaling is shown. The functional properties of ShcA phosphorylation leading to ERK1/2 kinase-dependent and -independent pathways in regulating the differentiation, the proliferation, and the trafficking of immature thymocytes are indicated.
