Table 1.

Estimated percentage of adults with borderline personality disorder (BPD) in the NESARC excluded from typical clinical trials of pharmacological treatments for BPD by traditional exclusion criteria.

	Borderline personality disorder patients (n = 2,231)
Exclusion variable*	% (N)	95% CI
Psychosis	5.22 (121)	4.11 – 6.60
Currently/past 12 months’ alcohol or drug abuse or dependence	29.87 (618)	27.48 – 32.37
Lifetime bipolar disorder	29.71 (663)	27.39 – 32.14
Current major depressive episode	19.25 (440)	17.38 – 21.25
Significant suicidal risk	2.16 (37)	1.43 – 3.25
Significant medical condition	32.54 (749)	30.19 – 34.99
Pregnancy/breastfeeding	1.16 (24)	0.71 – 1.90
Currently taking any psychotropic	NA	NA
Exclusion by at least one criterion	75.91 (1,692)	73.60 – 78.09

Percentages are weighted values.

^*Derived from the review of 21 pharmacological efficacy trials (method described in the paper).

Abbreviations: CI = confidence interval, NA = not available in NESARC, NESARC = National Epidemiologic Survey on Alcohol and Related Conditions.