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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Lupus. 2015 Apr;24(0):351–363. doi: 10.1177/0961203314556139

Figure 1. Aberrant signaling events in SLE T cells and potential therapeutic targets.

Figure 1

The lupus T cell is characterized by the downregulation of CD3ζ chain and its substitution by the FcRγ common chain. Following stimulation, FcRγ associates with Syk kinase, instead of ZAP-70, leading to heightened calcium responses and aberrant activation of calcineurin and CaMKIV. The increased magnitude of the early signaling events leads to a misbalance of the transcriptional machinery and results in aberrant gene expression. The white arrows with the star indicate potential therapeutic targets that are currently being considered for the management of SLE.