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. 2014 Nov 16;5(1):53. doi: 10.1186/2049-1891-5-53

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© Brooks et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic illustrating working hypothesis of the biological role of interferon tau (IFNT) and prostaglandins (PGs) in uterine function and conceptus elongation during early pregnancy in sheep. See text for detailed description. Legend: ABCC4, ATP-binding cassette, sub-family C (CFTR/MRP), member 4; CREB, cAMP responsive element binding protein; IFNAR, interferon (alpha, beta and omega) receptor; DP, prostaglandin D receptor (PTGDR); EP, prostaglandin E receptor (PTGER); FP, prostaglandin F receptor (PTGFR); IP, prostaglandin I receptor (PTGIR); PLA2, phospholipase A2; PPARD, peroxisome proliferator-activated receptor delta; PPARG, peroxisome proliferator-activated receptor gamma; PTGS2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); PG Synthases, prostaglandin synthases (AKR1C3, PTGDS, PTGES, PTGFS, PTGIS, TBXAS); SLCO2A1, solute carrier organic anion transporter family, member 2A1 (prostaglandin transporter); TBXA2R, thromboxane A2 receptor.