Table 3.
Frequency distribution of rs653765 and rs514049 genotypes and alleles in sepsis patients and healthy controls
| Cases (n = 440) (%) | Controls (n = 450) (%) | P | P * | Adjusted odds ratio (95% CI) | |
|---|---|---|---|---|---|
| rs653765 C > T | |||||
| CC | 346 (78.6) | 338 (75.1) | 0.234 | 0.234 | - |
| CT | 82 (18.6) | 91 (20.2) | - | - | - |
| TT | 12 (2.7) | 21 (4.7) | - | - | - |
| CC/CT | 428 (97.3) | 429 (95.3) | 0.126 | 0.234 | 1.746 (0.848, 3.594) |
| TT/CT | 94 (21.4) | 112 (24.9) | 0.213 | 0.234 | 0.820 (0.600, 1.121) |
| C | 774 (88.0) | 767 (85.2) | - | - | 1.000 (reference) |
| T | 106 (12.0) | 133 (14.8) | 0.091 | 0.234 | 0.790 (0.600, 1.039) |
| rs514049 A > C | |||||
| AA | 388 (88.2) | 394 (87.6) | 0.954 | 1.000 | - |
| AC | 48 (10.9) | 52 (11.6) | - | - | - |
| CC | 4 (0.9) | 4 (0.9) | - | - | - |
| AA/AC | 436 (99.1) | 446 (99.1) | 1.000 | 1.000 | 0.978 (0.243, 3.935) |
| AC/CC | 52 (11.8) | 56 (12.4) | 0.775 | 1.000 | 0.943 (0.630, 1.411) |
| A | 824 (93.6) | 840 (93.3) | 1.000 (reference) | ||
| C | 56 (6.4) | 60 (6.7) | 0.796 | 1.000 | 0.952 (0.653, 1.387) |
*False discovery rate-adjusted P-value for multiple hypotheses testing using the Benjamin-Hochberg method.