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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: J Immunol. 2014 Oct 22;193(11):5434–5443. doi: 10.4049/jimmunol.1401462

Figure 1. Pneumococcal infection induces dsDNA autoAb (IgA) production in C4-/- mice.

Figure 1

A) Mean (± SEM) dsDNA-specific serum IgM, IgG, and IgA levels in WT (n=6), C4-/-(n=7), and C3-/- (n=3) mice on day 0 and 14 following i.t. challenge with 107 CFU EF3030 as assessed by ELISA. Results are representative of 2 experiments. B) Mean ± (SEM) serum dsDNA-specific IgM, IgG, and IgA levels in Pneumovax-immune C4+/+ and C4-/- littermates over a 120-day period following i.p. challenge with 104 CFU WU2. C) DsDNA-specific serum IgA titers in C4+/+ and C4-/- littermates on day 0 and 120 days post-infection. Symbols represent titers of individual mice. Horizontal lines indicate mean values. D) DsDNA-specific serum IgA levels (mean ± SEM) in aged-matched naïve C4-/- mice over a 120-day period. In A-C, asterisks (*) indicate significant differences between the indicated groups (p<0.05).