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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: J Immunol. 2014 Oct 22;193(11):5434–5443. doi: 10.4049/jimmunol.1401462

Figure 2. Pneumovax or PPS-3 immunization induces anti-dsDNA Ab in C4-/- mice, with the highest levels observed in female mice.

Figure 2

A) Serum dsDNA-specific IgM, IgG, and IgA levels in WT (n=7) and C4-/- (n=7) female mice following i.p. immunization with Pneumovax. B-C) Mean (± SEM) serum dsDNA-specific IgM (B) and IgA (C) levels in WT and C4-/- female mice over a 120-day period following i.p. Pneumovax immunization. Day 0 and d120 endpoint titers are shown for C4-/- mice in C (right panel). D) Mean serum dsDNA-specific IgA levels in C4-/- mice following s.c. immunization with Pneumovax. E) Mean serum dsDNA-specific IgM and IgA levels in WT and C4-/- male mice on day 0 and 14 following i.p. immunization with 40 μg PPS3 (n=3 mice/group). F) Mean serum dsDNA-specific IgA levels in WT and C4-/- male (M) and female (F) mice on day 0 and 14 following i.p. immunization with 40 μg PPS3 (filled circles indicate individual mice). In A-F, asterisks (*) indicate significant differences between WT and C4-/- values, while pound signs (#) indicate significant differences between pre-immune and post-immune values for the same group (p<0.05).