Fig. 1.

Graph of hypersensitivity to MBP. Measurement of footpad thickness shows that MBP-tolerant mice developed a much smaller inflammatory reaction, than PBS- or ovalbumin (OVA)–treated mice, when MBP was injected subcutaneously into the footpad following MBP immunization. The Holm-Sidak test for pairwise comparisons was performed and the p values were less than the critical levels indicated in the figure (statistically significant). Six mice per group. Error bars represent the SEM.