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. 2015 Feb 27;16:6. doi: 10.1186/s12860-015-0048-6

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© Jia et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mps1 with a single leucine substituted in pNES1 relocate to the nucleus. (A) pNES1 motif is adjacent to the LXXLL motifs within TPR domain. (B) The subcellular distribution of wild type Mps1, Mps1 S821A, Mps1mutNES1, Mps1deltaA domain at G2/M boundary. (C) The centrosome localization of wild type Mps1 and Mps1mutNES. (D) The subcellular distribution of wild type Mps1, Mps1mutNES1-1, Mps1mutNES1-2, Mps1mutNES1-3, Mps1mutNES1-4 in interphase.