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. 2015 Mar 25;19(1):113. doi: 10.1186/s13054-015-0838-4

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© Wittekamp et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Time line of the two consecutive studies and interval period. (a) In both studies interventions were separated by a one month wash-in wash-out period (not shown) [3,6]. The baseline period is the control period in which ICUs used standard care, not including SDD or SOD. All centres continued SDD in the interval period (grey). The end of the intervention period marks the end of the study. ICU, intensive care unit; SDD, selective digestive tract decontamination; SOD, selective oropharyngeal decontamination.