Table 1. Summary of findings of ELLIPTA dry powder inhaler ease of use questionnaire and investigator assessment of inhaler technique for each study and when pooled together.
HZA106827 N=609 | FFA114496 N=219 | FFA115283 N=222 | Total N=1,050 | |
---|---|---|---|---|
Ease of use questionnaire | n=570 | n=213 | n=206 | N=989 |
How did you rate the ease of use of the inhaler?, n (%)
| ||||
Very easy | 362 (64) | 146 (69) | 132 (64) | 640 (65) |
Easy | 157 (28) | 64 (30) | 68 (33) | 289 (29) |
Neutral | 43 (8) | 3 (1) | 4 (2) | 50 (5) |
Difficult | 7 (1) | 0 | 2 (<1) | 9 (1) |
Very difficult | 1 (<1) | 0 | 0 | 1 (<1) |
How easily are you able to tell how many doses of medication are left in the inhaler?, n (%)
| ||||
Very easy | 419 (74) | 169 (79) | 144 (70) | 732 (74) |
Easy | 126 (22) | 42 (20) | 51 (25) | 219 (22) |
Neutral | 22 (4) | 2 (<1) | 8 (4) | 32 (3) |
Difficult | 3 (<1) | 0 | 1 (<1) | 4 (<1) |
Very difficult | 0 | 0 | 2 (<1) | 2 (<1) |
Inhaler use assessment
| ||||
Randomisation,a
n (%) | ||||
n | 609 | 218 | 222 | 1,049 |
Patient used the inhaler correctly | 578 (95) | 206 (94) | 216 (97) | 1,000 (95) |
1 Additional instruction required | 22 (4) | 11 (5) | 5 (2) | 38 (4) |
2 Additional instructions required | 8 (1) | 1 (<1) | 1 (<1) | 10 (1) |
3 Additional instructions required | 1 (<1) | 0 | 0 | 1 (<1) |
>3 Additional instructions required | 0 | 0 | 0 | 0 |
Week 2, n (%) | ||||
n | 593 | 215 | 216 | 1,024 |
Patient used the inhaler correctly | 593 (100) | 211 (98) | 216 (100) | 1,020 (>99) |
1 Additional instruction required | 0 | 3 (1) | 0 | 3 (<1) |
2 Additional instructions required | 0 | 1 (<1) | 0 | 1 (<1) |
3 Additional instructions required | 0 | 0 | 0 | 0 |
>3 Additional instructions required | 0 | 0 | 0 | 0 |
Week 4, n (%) | ||||
n | 569 | 213 | 206 | 988 |
Patient used the inhaler correctly | 569 (100) | 210 (99) | 205 (>99) | 984 (>99) |
1 Additional instruction required | 0 | 3 (1) | 1 (<1) | 4 (<1) |
2 Additional instructions required | 0 | 0 | 0 | 0 |
3 Additional instructions required | 0 | 0 | 0 | 0 |
>3 Additional instructions required | 0 | 0 | 0 | 0 |
Week 0; after one demonstration of correct usage.