Skip to main content
. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Semin Nephrol. 2014 Jun 13;34(4):384–393. doi: 10.1016/j.semnephrol.2014.06.005

Table 1. Minimum design criteria to generate a transplantable bioengineered kidney graft that can produce a filtrate.

This table outlines basic components needed to generate a single kidney that is capable of filtering.

Structure Scaffold

  • Biocompatible (non-toxic to cells and recipient)

  • Outline basic organ architecture (artery, vein, ureter, parenchyma)

  • Maintain integrity during culture and post-implantation
Cells

  • Viable

  • Basic function

Organ assembly

  • Enable perfusion, filtration, and drainage of filtrate during culture and post-impantation

Function Filtration

  • Excretion and reabsorption to maintain balance of

    • electrolytes

    • acid/base

    • volume
Safety Implantation

  • Surgical anastomoses and tissue handling comparable to donor organ

  • Vascular integrity to prevent hemorrhage and coagulation
Minimize antigenicity

  • Scaffold

  • Cells

Sterility
Clinical monitoring

  • Durability of the construct