Table 1.
| Compound |
aLogTCID50 (viral titer) |
bFold decrease in replication |
|---|---|---|
| Control (DMSO) | 8.5 | - |
| A1 | 7.1 | 25 |
| A8 | 7.1 | 25 |
| A9 | 5.7 | 630 |
| A11 | 6.8 | 50 |
| A12 | 6.2 | 200 |
| A13 | 6.5 | 100 |
| A14 | 6.3 | 158 |
| A15 | 5.8 | 500 |
| A16 | 6.5 | 100 |
a
Viral titer, expressed as logTCID50, was determined from supernatants of MDCK cells infected for 48 hours and treated for the entire period with 50 µM of the indicated compounds.
b
Fold decrease in virus replication was determined by subtracting the logTCID50 value for each compound from 8.5 (control value, see Table) and calculating the inverse log.