Table 1.

The family of caveolins: genomic localization, cell- and tissue-specific expression and principal knockout mouse phenotypes

Human gene	Chromosomal localization	Expression patterns	Knockout mouse phenotypes
Cav-1	7q31.1	Adipocytes	Diabetes [40, 41]
		Cardiac fibroblasts	Lung diseases [26, 42, 43]
		Endothelia	Heart diseases [42, 44]
		Macrophages	Cerebral ischaemia [45–47]
		Neural cells	Predisposition to skin and breast cancer [54, 75–79]
		Pneumocytes	Protection from prostate cancer [80]
		Smooth muscle cells
		Striated muscle cells
Cav-2	7q31.1	Same as Cav-1	Impaired pulmonary functionality [48]
			Abnormalities in skeletal muscle [49]
Cav-3	3p25	Striated muscle cells	Mild myopathic changes [27, 28]
		Smooth muscle cells	Cardiomyopathy [50]
		Cardiac myocytes	Insulin resistance and increased adiposity [51]