Fig 6.

Effect of cADPR on cell proliferation in human MSCs. (A) Cyclic ADP ribose increased cell proliferation (assessed by MTT assay) in a concentration-dependent manner. The effect was antagonized by 100 μM 8-Br-cADPR. n = 10, *P < 0.05, **P < 0.01 versus 0 μM cADPR. (B) Cyclic ADP ribose increased ³H-thymidine incorporation in a concentration-dependent manner, and the effect was antagonized by 100 μM 8-Br-cADPR. n = 10, *P < 0.05, **P < 0.01 versus 0 μM cADPR. (C) Cyclic ADP ribose did not increase ³H-thymidine incorporation in cells transfected with TRMP2 siRNA A or B. n = 10, *P < 0.05 versus without cADPR application.