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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Lancet Neurol. 2014 Nov 3;13(12):1193–1201. doi: 10.1016/S1474-4422(14)70238-8

Figure 2. Cumulative hazard (accumulated risk rate) of motor diagnosis by CAG-Age Product (CAP) for various baseline predictor values.

Figure 2

CAP is age corrected for CAG expansion and is the time metric of the horizontal axis. The solid black line denotes the cumulative hazard for a model with no predictor representing prediction based only on CAG and age (as summarized by CAP). The dash-dot lines are risk profiles for predictors representing no deterioration at baseline (e.g., Total Motor Score=0), whereas the colored solid lines are risk profiles for predictors representing advanced deterioration at baseline (e.g., Total Motor Score = 15). Putamen volume is ICV-corrected. As a reference, CAP=290 corresponds to age 31 and CAP=600 corresponds to age 64 for a person with CAG=43 (the sample mean). CAP=Age × (CAG − 33·66).CAG=cytosine-adenine-guanine.