Figure 5.
Myxoma virus inhibited tumor growth following a single intratumoral administration but had no effect on tumors in the contralateral hemisphere. A, myxoma virus did not increase survival in nude mice with bilateral U87 tumors in which only the ipsilateral tumor was injected with 5 × 106 PFUs vMyxgfp. B, representative H&E-stained sections show the inoculated tumor was very small (arrow) or absent whereas the tumor in the contralateral hemisphere was very large (right). Dead myxoma virus–treated animals had large tumors in both hemispheres (left).