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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: Hum Mutat. 2014 Dec;35(12):1506–1513. doi: 10.1002/humu.22701

Figure 1.

Figure 1

Schematic representation of cochlin domain structure with an N-terminal signal peptide (SP), followed by a Limulus factor C, cochlin, and late gestation lung protein, Lgl1 (LCCL) domain, two von Willebrand factor A-like (vWFA) domains, and two short lengths of intervening domains (ivd1 and ivd2). A total of 21 mutations have been reported, eight of which (marked red) were investigated in this study. Three HA epitope tags were added at the C-terminal end of the COCH sequences (C=cysteine residue).