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. 2015 Mar 25;16(1):55. doi: 10.1186/s13059-015-0616-2

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© Leung et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Coverage performance and metrics. (a) Coverage depth diagram. (b) Coverage depth data for G1/0 and G2/M single cells. (c) Coverage breadth diagram. (d) Coverage breadth data for exome region of G1/0 and G2/M single cells compared to previous studies using SNS [7] and MALBAC (Ni et al. [28]). Error bars show SEM. (e) Coverage uniformity diagram. (f) Coverage depth distribution for sites with low coverage in G1/0 and G2/M single cells. (g) Lorenz curves of coverage uniformity, showing values for perfect coverage, millions of SKN2 reference cells, Nuc-Seq single cell [11], single cells from G1/0 and G2/M distributions, and SNS cell [7]. (h) Capture performance of sequence reads across exons in the KRT76 locus for three single cells.