Table 1.

Fluorination and Ligands Enable Regioselective Allylation Reactions.^[a]

^[a]Catalyst System A: substrate (1.0 equiv), Pd(OAc)₂ (3.0 mol%), t-BuBrettPhos (6.0 mol%), 1,4-dioxane (0.50 M), 60 °C, 20 h; Catalyst System B: substrate (1.0 equiv), Pd(OAc)₂ (2.5 mol%), PhXPhos (5.0 mol%), 1,4-dioxane (0.10 M), 90 °C, 20 h. For fluorinated products, yields and selectivities were determined by ¹⁹F NMR using PhCF₃ or PhF as an internal standard, respectively. For non-fluorinated products, yields and selectivities were determined by ¹H NMR using CH₂Br₂ as an internal standard.